Cloning and characterization of the 5' part of the high molecular weight transcript of rat DNA polymerase beta. | Zendy

Ryszard Konopiński | Zendy; Radosława Nowak | Zendy; Janusz A. Siedlecki | Zendy

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Cloning and characterization of the 5' part of the high molecular weight transcript of rat DNA polymerase beta.

Author(s) -

Ryszard Konopiński,

Radosława Nowak,

Janusz A. Siedlecki

Publication year - 1995

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1995_4655

Subject(s) - microbiology and biotechnology , dna polymerase , polyadenylation , dna polymerase beta , polymerase , molecular cloning , biology , dna polymerase i , cloning (programming) , complementary dna , dna polymerase ii , gene , dna clamp , open reading frame , dna polymerase mu , genetics , messenger rna , polymerase chain reaction , reverse transcriptase , dna repair , peptide sequence , circular bacterial chromosome , base excision repair , computer science , programming language

A rat brain cDNA library has been constructed. Three identical clones of about 2.2 kb representing high molecular weight DNA polymerase beta transcript were found. Sequencing proved our earlier suggestion that both high and low molecular weight DNA polymerase beta transcripts have the same open reading frame and differ mainly at the 3' end. Because of that, alternative polyadenylation is discussed as a possible mechanism for tissue- and development-specific regulation of the DNA polymerase beta gene expression.

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