Nonhistone chromosomal proteins (NHCP) in adenocarcinoma of human endometrium. | Zendy

R Miturski | Zendy

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Nonhistone chromosomal proteins (NHCP) in adenocarcinoma of human endometrium.

Author(s) -

R Miturski

Publication year - 1995

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1995_4644

Subject(s) - endometrium , nucleus , adenocarcinoma , biology , endometrial cancer , cancer , cell nucleus , medicine , endocrinology , chemistry , microbiology and biotechnology , genetics

Concentration and electrophoretic pattern of nonhistone chromosomal proteins (NHCP) in cancer and normal endometrium were examined. In normal tissues the NHCP/DNA ratio ranged from 0.6 to 0.8 whereas in malignant tissues from 1.2 to 1.7. Mean nuclear concentration of NHCP was 14.16 pg/cell nucleus of normal endometrium and 33.35 pg/cell nucleus of cancer tissue. The two tissues differed in the electrophoretic pattern. Heavy fractions (> 60 kDa--36%) predominated in normal tissue whereas light fractions (< 30 kDa--48%) in malignant tissue samples. The percentage of intermediate fractions (30-60 kDa) was similar. Neoplastic endometrium shows, irrespective of the patient's age, a high NHCP content. It seems that NHCP, especially the fraction extracted with 0.35 M NaCl, because of its tissue and cell specificity are involved in neoplasm formation.

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