Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report | Zendy

Luca Negosanti | Zendy; Rossella Sgarzani | Zendy; Matteo Santoli | Zendy; M Negosanti | Zendy; Nicoletta Banzola | Zendy; Francesca Negosanti | Zendy

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Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

Author(s) -

Luca Negosanti,

Rossella Sgarzani,

Matteo Santoli,

M Negosanti,

Nicoletta Banzola,

Francesca Negosanti

Publication year - 2016

Publication title -

journal of surgical dermatology

Language(s) - English

Resource type - Journals

eISSN - 2424-9165

pISSN - 2424-9084

DOI - 10.18282/jsd.v1.i1.36

Subject(s) - actinic keratosis , dermatology , erythema , medicine , photodynamic therapy , scalp , skin reaction , keratosis , chemistry , basal cell , organic chemistry

Ingenol mebutate (IM) was recently introduced for the treatment of actinic keratosis (AK). It is considered a safe and effective treatment in spite of local reactions frequently reported. These reactions may consist of erythema, flaking, crusting, swelling, vesicles and erosions, and would usually spontaneously recede within 20–30 days. We reported a case of a patient affected by multiple actinic keratosis of the scalp treated with IM. The patient reported a severe reaction that was not solved in two months. We decided to treat the reaction with photodynamic therapy and aminolevulinic acid. This treatment was demonstrated to be effective in solving this severe side effect.

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