Intracranial Hypertension Condition Monitoring By Time Domain Analysis

This paper discusses the developments in the assessment of intracranial hypertension in humans and recent research carried out by the authors on the techniques for the non-invasive measurement of intracranial pressure. A brief historical review sets the scene with regard to clinical and invasive pressure can be predicted. Although a simulation and a frequency domain analysis of the dynamics of the human brain has been carried out, due to space constraints, this paper concentrates only on the time domain experiments and analysis that were used in developing a non-invasive approach to the measurement of intracranial pressure. The time domain analysis uses the crosscorrelation of the non-invasive blood flow of the middle cerebral artery with blood pressure measurements and their varying phase shift with trauma characteristics to make predictions of intracranial pressure trends that lead to pathologically dangerous conditions. The paper concludes with a section concerning the development of software and associated graphical displays that could inform the nursing staff of trends in intracranial pressure and life threatening conditions so that immediate action can be taken.