PPARγ: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland | Zendy

Peng-yue Mu | Zendy; Chenchen Chu | Zendy; Yu Di | Zendy; Yan Shao | Zendy; Shaozhen Zhao | Zendy

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PPARγ: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland

Author(s) -

Peng-yue Mu,

Chenchen Chu,

Yu Di,

Yan Shao,

Shaozhen Zhao

Publication year - 2020

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2020.06.02

Subject(s) - lacrimal gland , medicine , endocrinology , conjunctiva , tumor necrosis factor alpha , receptor , immunology , pathology

Among PPARs, PPARγ might play a dominant role in the regulation of metabolic- and inflammatory-signaling pathways on the ocular surfaces and in lacrimal glands. Down-regulation of PPARγ is highly relevant to lacrimal gland dysfunction under desiccating-stress and diabetic conditions. PPARγ, thus, is a potential therapeutic target in the treatment of environment- or diabetes-induced dry eye diseases.

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