High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway | Zendy

Panpan Yao | Zendy; Minjie Sheng | Zendy; Wenhao Weng | Zendy; Yin Long | Zendy; Hao Liu | Zendy; Li Chen | Zendy; Jiajun Lu | Zendy; Ao Rong | Zendy; Bing Li | Zendy

Open Access

High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway

Author(s) -

Panpan Yao,

Minjie Sheng,

Wenhao Weng,

Yin Long,

Hao Liu,

Li Chen,

Jiajun Lu,

Ao Rong,

Bing Li

Publication year - 2019

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2019.12.01

Subject(s) - chop , apoptosis , tunel assay , caspase 3 , kinase , caspase 12 , medicine , microbiology and biotechnology , signal transduction , programmed cell death , caspase , biology , biochemistry

To investigate the effect of high concentration of glucose (HCG) on double stranded RNA-activated protein kinase-like ER kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)-transcription factor C/EBP homologous protein (CHOP)-cysteine aspartate specific proteinase (caspase-12) signaling pathway activation and apoptosis in rabbit corneal epithelial cells (RCECs).

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