Myopia genetics in genome-wide association and post-genome-wide association study era | Zendy

Xuan Liao | Zendy; QingQing Tan | Zendy; ChangJun Lan | Zendy

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Myopia genetics in genome-wide association and post-genome-wide association study era

Author(s) -

Xuan Liao,

QingQing Tan,

ChangJun Lan

Publication year - 2019

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2019.09.18

Subject(s) - genome wide association study , genetic association , medicine , association (psychology) , computational biology , genome , data science , genetics , biology , single nucleotide polymorphism , genotype , computer science , gene , philosophy , epistemology

Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omics era.

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