Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review | Zendy

Shangli Ji | Zendy; Shibo Tang | Zendy

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Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review

Author(s) -

Shangli Ji,

Shibo Tang

Publication year - 2019

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2019.01.22

Subject(s) - induced pluripotent stem cell , medicine , neuroscience , glaucoma , retinal , blindness , retina , retinal ganglion cell , ophthalmology , microbiology and biotechnology , biology , embryonic stem cell , optometry , genetics , gene

Glaucoma is a common optic neuropathy that is characterized by the progressive degeneration of axons and the loss of retinal ganglion cells (RGCs). Glaucoma is one of the leading causes of irreversible blindness worldwide. Current glaucoma treatments only slow the progression of RGCs loss. Induced pluripotent stem cells (iPSCs) are capable of differentiating into all three germ layer cell lineages. iPSCs can be patient-specific, making iPSC-derived RGCs a promising candidate for cell replacement. In this review, we focus on discussing the detailed approaches used to differentiate iPSCs into RGCs.

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