Amyloid beta deposition related retinal pigment epithelium cell impairment and subretinal microglia activation in aged APPswePS1 transgenic mice | Zendy

Zhizhang Dong | Zendy; Juan Li | Zendy; Yifeng Gan | Zendy; Xuerong Sun | Zendy; Yunxia Leng | Zendy; Jian Ge | Zendy

Open Access

Amyloid beta deposition related retinal pigment epithelium cell impairment and subretinal microglia activation in aged APPswePS1 transgenic mice

Author(s) -

Zhizhang Dong,

Juan Li,

Yifeng Gan,

Xuerong Sun,

Yunxia Leng,

Jian Ge

Publication year - 2018

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2018.05.06

Subject(s) - genetically modified mouse , retinal pigment epithelium , pathology , retinal , retina , microglia , transgene , retinal degeneration , h&e stain , immunohistochemistry , medicine , microbiology and biotechnology , chemistry , biology , inflammation , ophthalmology , biochemistry , neuroscience , gene

To identify the pathological role of amyloid beta (Aβ) deposition in retinal degeneration, and explore Aβ deposition on the retinal pigment epithelium cells (RPE) layer and the associated structural and functional changes in Alzheimer's disease transgenic mice.

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