The role of microglia in the progression of glaucomatous neurodegeneration- a review | Zendy

Huilan Zeng | Zendy; Jingming Shi | Zendy

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The role of microglia in the progression of glaucomatous neurodegeneration- a review

Author(s) -

Huilan Zeng,

Jingming Shi

Publication year - 2018

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2018.01.22

Subject(s) - neurodegeneration , medicine , glaucoma , neuroscience , microglia , retinal ganglion cell , optic nerve , ophthalmology , pathology , inflammation , biology , disease , immunology

Glaucoma is a serious leading cause of irreversible blindness worldwide. Reducing intraocular pressure (IOP) does not always stop glaucomatous neurodegeneration and the optic nerve may continue to be damaged in the normal IOP. Microglial activity has been recognized to play essential roles in pathogenesis of the central nervous system (CNS) as well as retinal ganglion cell (RGC) survival. The relationship between the neurodegeneration and the microglia cells in glaucoma is very complicated and still remains unclear. In the present review, we summarize the recent studies of mechanisms of microglia in glaucoma neurodegeneration, which might provide new ways to treat glaucoma.

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