Upregulated inflammatory associated factors and blood-retinal barrier changes in the retina of type 2 diabetes mellitus model | Zendy

Ruijin Ran | Zendy; Xiaoying Zheng | Zendy; Liping Du | Zendy; Xuedong Zhang | Zendy; Xiaoli Chen | Zendy; Shenyin Zhu | Zendy

Open Access

Upregulated inflammatory associated factors and blood-retinal barrier changes in the retina of type 2 diabetes mellitus model

Author(s) -

Ruijin Ran,

Xiaoying Zheng,

Liping Du,

Xuedong Zhang,

Xiaoli Chen,

Shenyin Zhu

Publication year - 2016

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2016.11.09

Subject(s) - medicine , endocrinology , insulin resistance , diabetes mellitus , blood–retinal barrier , streptozotocin , retina , type 2 diabetes mellitus , insulin , western blot , h&e stain , retinal , diabetic retinopathy , immunohistochemistry , chemistry , biology , ophthalmology , biochemistry , neuroscience , gene

To examine the expression of high mobility group box-1 (HMGB-1) and intercellular adhesion molecule-1 (ICAM-1) in the retina and the hippocampal tissues; and further to evaluate the association of these two molecules with the alterations of blood-retinal barrier (BRB) and blood-brain barrier (BBB) in a rat model of type 2 diabetes.

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