Aquaporin-1 down regulation associated with inhibiting cell viability and inducing apoptosis of human lens epithelial cells | Zendy

Honghua Zheng | Zendy; Guoxing Xu | Zendy; Jian Guo | Zendy; Licheng Fu | Zendy; Yao Yao | Zendy

Open Access

Aquaporin-1 down regulation associated with inhibiting cell viability and inducing apoptosis of human lens epithelial cells

Author(s) -

Honghua Zheng,

Guoxing Xu,

Jian Guo,

Licheng Fu,

Yao Yao

Publication year - 2015

Publication title -

international journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 29

eISSN - 2227-4898

pISSN - 2222-3959

DOI - 10.18240/ijo.2016.01.03

Subject(s) - viability assay , apoptosis , flow cytometry , transfection , small interfering rna , microbiology and biotechnology , cell , tunel assay , blot , rna interference , gene silencing , cell growth , medicine , cell culture , biology , rna , gene , biochemistry , genetics

To investigate the role of Aquaporin-1 (AQP-1) in lens epithelial cells (LECs) and its potential target genes. AQP-1 is specifically expressed in LECs of eyes and is significant for lens homeostasis and transparency maintenance. Herein, AQP-1 expression in LECs was investigated to evaluate its influence on cell survival in association with its potential role in cataract formation.

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