Histomorphological study of invasive breast carcinoma and its prognostic scoring using Nottingham prognostic index

Breast carcinoma is the common malignant tumor in women accounting for 15% of cancerrelated deaths. Clinical history, examination and use of mammography has improved the diagnosticapproach to breast cancer. Nottingham prognostication index is considered to be a useful marker thattakes into consideration some of the important factors like tumor size, histologic grade and lymphnodestage.Aims and Objectives: 1. To study histomorphological distribution pattern of various invasive breastcarcinoma. 2. To estimate prognosis by using Nottingham prognostic index score.Materials and Methods: One year six months descriptive study was performed which included all theinvasive breast carcinoma cases comprising of mastectomy specimen with lymphnode sampling. Based ontumor size, histologic grade and lymphnode stage; Nottingham prognostic index score was calculated andcases were categorised into different prognostic group.Results: 68 cases were included in the study with 67 female patients and one male patient.Histopathologically, 80.88% were Infiltrating ductal carcinoma – not otherwise specified. Tumor sizebelonging to T2 in 66.17%. 45.58% showed no lymphnode involvement and 33.82% belonged tolymphnode stage N1. Majority (50%) belonged to histologic grade II. Nottingham Prognostic Index (NPI)score in 42.64% showed moderate prognosis.Conclusion: Histomorphological study showed commonest lesion to be Infiltrating Ductal carcinomanototherwise specified and majority belonged to moderate prognosis category according to NottinghamPrognostic Index score.Keywords: Histomorphology, Infiltrating ductal carcinoma, Tumor size, Nottingham Prognostic index.