Synthesis, physicochemical characterization and analgesic evaluation of some new thieno [2,3-D] Pyrimidin 4(3H) one derivatives | Zendy

Dinesh Prakashrao Kawade | Zendy; Dinesh Chaple | Zendy; Pramod B. Khedekar | Zendy

Open Access

Synthesis, physicochemical characterization and analgesic evaluation of some new thieno [2,3-D] Pyrimidin 4(3H) one derivatives

Author(s) -

Dinesh Prakashrao Kawade,

Dinesh Chaple,

Pramod B. Khedekar

Publication year - 2020

Publication title -

international journal of pharmaceutical chemistry and analysis

Language(s) - English

Resource type - Journals

eISSN - 2394-2797

pISSN - 2394-2789

DOI - 10.18231/j.ijpca.2020.005

Subject(s) - analgesic , chemistry , elemental analysis , microwave irradiation , tramadol , solvent , fourier transform infrared spectroscopy , hot plate , nuclear chemistry , organic chemistry , catalysis , materials science , pharmacology , chemical engineering , medicine , composite material , engineering

A POCl3 catalyzed, efficient, one-step and solvent-free synthesis of novel thieno [2,3-d] pyrimidin-4(3H)-one derivatives from 2-amino-4,5-substitutedthiophene-3-carbonitrile has been developed using various aliphatic acid under both conventional heating and microwave irradiation techniques. The formation of compounds was confirmed via elemental analysis and spectroscopic techniques like FTIR, 1HNMR and mass spectroscopy. All synthesized compounds have been screened for their analgesic activity by using Eddy´s hot plate method. The synthesized compounds 2d, 2k and 2h showed good analgesic activity and compounds 2a, 2b, 2g and 2i showed moderate whereas remaining compounds possessed less analgesic activity compared with standard, Tramadol. Keywords: POCl3, Thieno[2,3-d]pyrimidin-4 (3H)-one, Analgesic activity, Eddy´s hot plate.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research