Effect of heparinized irrigation solution on postoperative inflammation after cataract surgery in diabetics– A randomized control study

Purpose: To evaluate the influence of heparinized irrigation solution on postoperative inflammation onanterior chamber cellular reaction (ACR) after cataract surgery in diabetics.Materials and Methods: 120 patients of 164 patients selected for the study who completed 2 monthsfollow up were included in this study. Patients with controlled blood sugar levels with cataract attendingR.L. Jalappa Hospital OPD (Outpatient department) were selected. Consecutive patients were segregatedinto 2 groups. All patients underwent manual small incision cataract surgery (MSICS) under peribulbaranaesthesia performed by a single surgeon. Superior 6mm sclerocorneal tunnel was made and cataract wasextracted and rigid PMMA (Polymethyl metha acrylate) lens was implanted in the bag. The remainingviscoelastic substance was replaced by balanced salt solution (BSS).In group 1, 5000 IU Low molecular weight heparin (LMWH) was added to balanced salt solution of 500ml and hence the final concentration was 10 IU/ml of BSS. In group 2 heparin was not added to BSS.Post operative anterior chamber (AC)reaction were noted on first postoperative day, after 1 week, 1 monthand 2 months. Intraoperative hyphaema, postoperative shallow AC and hyphaema were documented. TheAC reaction was noted by (Standard Uvea Nomenclature) SUN classification system. It is a prospectiverandomized control trial. Statistical analysis was done by Chi-square test.Results: Anterior chamber reaction was statistically significant between the two groups at Day 1 and Day 7postoperatively with p value being postoperative months with p value being statistically in significant.Postoperative complications such as Cystoid macular oedema (CME) was seen in 4 patients in group 2 and1 patient in group 1. Pigments on IOL was seen in 14 pts and 3 pts of group 1 and 2 respectively.Conclusion: Addition of heparin to irrigating solution showed statistically significant lesser AC reactionin Group 1 than Group 2 at first and