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Minimal surgical access techniques have become a gold standard of patient care in present era, laparoscopic cholecystectomy is preffered treatment of choice for gall stones. Along with advantages, it is also associated with severe sympathoadrenal stress response, a cause for morbidity and mortality. Dexmedetomidine is an highly selective alpha2 adrenoceptor (α2-AR) agonist, seems to control this sympathetic response and provide a stable perioperative haemodynamics. Aim of the Study: To investigate effects of preoperative single bolus dose of Dexmedetomidine on hemodynamic parameters in patients posted for Elective Laparoscopic Cholecystectomy. Design: Randomised Prospective Double-Blind Study. Materials and Methods: 50 ASA Gr I & II patients belonging to both sex in age group of 20 to 50yrs scheduled for Elective Laparoscopic Cholecystectomy were randomly divided into two groups of 25 each Group-D (Dexmedetomidine) and Group – S (Placebo (0.9% Saline)) A Balanced General Anaesthesia technique included Propofol, Vecuronium IPPV & Isoflurane 0.5%. Perioperatively SBP, DBP, MAP, HR were recorded at predetermined intervals Pre-op, After Induction, After Intubation & 15 mins interval and extubation data was analysed statistically. Results: In Group D HR, MAP, SBP, DBP were significantly less in comparision to Group S. Conclusion: A single bolus dose of Dexmedetomidine preoperatively effectively attenuates sympathoadrenal stress responses to laparoscopy results in stable perioperative hemodynamics.

Effects of preoperative single bolus dose of dexmedetomidine on perioperative hemodynamics in elective laparoscopic cholecystectomy