Effects of preoperative single bolus dose of dexmedetomidine on perioperative hemodynamics in elective laparoscopic cholecystectomy

Minimal surgical access techniques have become a gold standard of patient care in present era, laparoscopic cholecystectomy is preffered treatment of choice for gall stones. Along with advantages, it is also associated with severe sympathoadrenal stress response, a cause for morbidity and mortality. Dexmedetomidine is an highly selective alpha2 adrenoceptor (α2-AR) agonist, seems to control this sympathetic response and provide a stable perioperative haemodynamics. Aim of the Study: To investigate effects of preoperative single bolus dose of Dexmedetomidine on hemodynamic parameters in patients posted for Elective Laparoscopic Cholecystectomy. Design: Randomised Prospective Double-Blind Study. Materials and Methods: 50 ASA Gr I & II patients belonging to both sex in age group of 20 to 50yrs scheduled for Elective Laparoscopic Cholecystectomy were randomly divided into two groups of 25 each Group-D (Dexmedetomidine) and Group – S (Placebo (0.9% Saline)) A Balanced General Anaesthesia technique included Propofol, Vecuronium IPPV & Isoflurane 0.5%. Perioperatively SBP, DBP, MAP, HR were recorded at predetermined intervals Pre-op, After Induction, After Intubation & 15 mins interval and extubation data was analysed statistically. Results: In Group D HR, MAP, SBP, DBP were significantly less in comparision to Group S. Conclusion: A single bolus dose of Dexmedetomidine preoperatively effectively attenuates sympathoadrenal stress responses to laparoscopy results in stable perioperative hemodynamics.