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A comparative analysis of molecular genetic phenotypes of mucous membrane cells in five anatomical regions  of the colon in a group of healthy donors was conducted by comparing mRNA expression profiles of 62 genes  involved in the regulation of vital cellular function. We used 181 biopsy samples of morphologically unchanged  colonic mucosa, obtained from the colon (ascending, transverse-colon, descending, sigmoid) and rectum sections  during prophylactic colonoscopy of 58 donors with no colon pathology. The mRNA levels for 62 genes involved  in the regulation of apoptosis, proliferation, transcription, differentiation, cell-cell adhesion, and immune response were  assessed by RT-PCR. Statistically significant differences were found for the molecular phenotypes of five sections  of the colon. The results of the study can serve as a basis for creating a reference database (values of expression profiles),  developing methods of differential diagnostics and screening of various pathologies of the colon.

The study of mRNA expression profiles of main cell function regulator genes in unchanged colonic mucosa from healthy donors