Open AccessExpression of ganglioside GD2 on colorectal adenocarcinoma cells
Author(s) -
А. Yu. Lupatov,
A. M. Gisina,
Yan Kim,
S. A. Bykasov,
Н. Н. Волченко,
Д. В. Сидоров,
K. N. Yarygin,
Р. В. Холоденко
Publication year - 2020
Publication title -
biomeditsinskaya khimiya
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.192
H-Index - 15
eISSN - 2310-6972
pISSN - 2310-6905
DOI - 10.18097/pbmc20206601095
Subject(s) - ganglioside , colorectal cancer , adenocarcinoma , flow cytometry , cancer research , cell culture , colorectal adenocarcinoma , cancer stem cell , cell , medicine , cancer , pathology , biology , immunology , biochemistry , genetics
Using flow cytometry GD2 ganglioside expression was evaluated both on colorectal adenocarcinoma cell lines and on tumor tissue samples from colorectal cancer patients. The marker was found on EpCAM-positive tumor cells in 6 of 12 patients' samples but not on the HT29 and CaCo-2 cell lines. GD2 expression was not an exceptional feature of cancer stem cells, since its expression level was similar on CD133-positive and CD133-negative tumor cells. Thus, the presence of GD2 ganglioside was revealed on colorectal adenocarcinoma cells for the first time. This finding makes it possible to use targeted therapy to treat this disease.
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