Development of drugs on the basis of high-polymeric double-stranded RNA for antiviral and antitumor therapy | Zendy

Е. Д. Даниленко | Zendy; A. O. Belkina | Zendy; Г. М. Сысоева | Zendy

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Development of drugs on the basis of high-polymeric double-stranded RNA for antiviral and antitumor therapy

Author(s) -

Е. Д. Даниленко,

A. O. Belkina,

Г. М. Сысоева

Publication year - 2019

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20196504277

Subject(s) - rna silencing , immunoadjuvant , innate immune system , rna , mda5 , immune system , biology , rna interference , virology , immunology , biochemistry , gene

The review summarizes literature data on the development of drugs based on natural and synthetic high-polymeric double-stranded RNA, and their antiviral, immunoadjuvant and antitumor properties. Special attention is paid to cell receptors responding to exogenous dsRNA, the paths of dsRNA-dependent antiviral reaction, ability of dsRNA to inhibit growth and induce apoptosis ofmalignant cells. It has been shown that enhancing the innate immune response with dsRNA can be an effective component in improving methods for treating and preventing infectious and cancer diseases. The further use of dsRNA for the correction of pathological processes of different origin is discussed

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