Hepatoprotective activity of aqueous extract from Caragana jubata (Pall.) Poir. shoots in the model of acute hepatitis induced by acetaminophen in rats | Zendy

Павел Алексеевич Какорин | Zendy; I. V. Babenkova | Zendy; Yu. O. Teselkin | Zendy; G. V. Rаmenskаya | Zendy; Т А Демура | Zendy; В. Г. Кукес | Zendy

Open Access

Hepatoprotective activity of aqueous extract from Caragana jubata (Pall.) Poir. shoots in the model of acute hepatitis induced by acetaminophen in rats

Author(s) -

Павел Алексеевич Какорин,

I. V. Babenkova,

Yu. O. Teselkin,

G. V. Rаmenskаya,

Т А Демура,

В. Г. Кукес

Publication year - 2018

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20186403241

Subject(s) - acetaminophen , shoot , traditional medicine , aqueous extract , chemistry , aqueous medium , aqueous solution , pharmacology , biology , medicine , biochemistry , botany , organic chemistry

The aim of the study was to investigate the hepatoprotective activity of an aqueous extract of Caragana jubata (Pall.) Poir. Acute experimental hepatitis was induced by acetaminophen administration of 1000 mg/kg. Studies were conducted in white Wistar rats. The aqueous extract of C. jubata demonstrated the hepatoprotective effect, comparable to that of the reference preparation “Carcil”. This was manifested by the normalization of biochemical blood parameters (ALT, AST, alkaline phosphatase, cholesterol, total bilirubin) and antioxidant activity of liver homogenates, determined by the method based on oxidation of luminol induced by 2,2¢-azo-bis-2-amidinopropane. Normalization of morphofunctional indices was also shown in a histological study of liver of rats that received aqueous extract from C. jubata.

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