Methods for determining of cytochrome P450 isozymes functional activity | Zendy

Alexey V. Kuzikov | Zendy; Rami A. Masamrekh | Zendy; А. I. Archakov | Zendy; V.V. Shumyantseva | Zendy

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Methods for determining of cytochrome P450 isozymes functional activity

Author(s) -

Alexey V. Kuzikov,

Rami A. Masamrekh,

А. I. Archakov,

V.V. Shumyantseva

Publication year - 2018

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20186402149

Subject(s) - resonance raman spectroscopy , chemistry , cytochrome p450 , electron paramagnetic resonance , isozyme , surface plasmon resonance , raman spectroscopy , nuclear magnetic resonance , nanotechnology , biochemistry , enzyme , materials science , physics , nanoparticle , optics

The review is dedicated to modern methods and technologies for determining of cytochrome P450 isozymes functional activity, such as absorbance and fluorescent spectroscopy, electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), Raman, Mossbauer, and X-ray spectroscopy, surface plasmon resonance (SPR), atomic force microscopy (AFM). Methods of molecular genetic analysis were reviewed from personalized medicine point of view. The use of chromate-mass-spectrometric methods for cytochrome P450-dependent catalytic reactions' products was discussed. The review covers modern electrochemical systems based on cytochrome P450 isozymes for their catalytic activity analysis, their use in practice and further development perspectives for experimental pharmacology, biotechnology and translational medicine.

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