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To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using  exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles  is required. In the present work, universal proteins have been identified, their expression has been increased  in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer.  The use of antibodies against major exosomal proteins will further develop a simple and high-performance method  of affinity isolation of tumor exosomes.

Comparative sub-population analysis of exosomes from blood plasma of cancer patients