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Matrix metalloproteinases (MMPs) responsible for the extracellular matrix remodeling, the activation of various  growth factors, and angiogenesis play an important role in the colorectal cancer (CRC) development. In the present  work the comparative analysis of MMP-7, -8, -9, and -11 mRNA as well mRNA of the Ki-67 proliferation marker  in tissue samples obtained from CRC patients and healthy individuals. Employing the real time PCR method  the expression levels of several MMPs (MMP-7, -8, -9, and -11) and cell proliferation marker, Ki-67, were  simultaneously measured in 256 tissue samples obtained from 112 patients with CRC: 112 samples of the primary  tumor (CRC), 112 samples of the most distant border of morphologically normal colonic mucosa (MNT), 16 samples  of liver metastases) and from 16 healthy volunteers who underwent colonoscopy and biopsy. The expression  of both MMPs studied and Ki-67 was found to be elevated in CRC primary tumors and liver metastases compared  with the normal mucosa. CRC tumor and metastatic cells exhibited similar proliferative activity. The metastases  are characterized by the highest cross-correlation of MMPs among tissue types tested. For the first time it was shown  that normal mucosa from healthy individuals and CRC patients varied in the MMP-8 expression level. They also  had dissimilar MMP correlation patterns thus suggesting that epithelial cells adjusted to CRC tumor differ from  mucosal epithelial cells of healthy individuals.

biomedicinskaâ himiâ

Comparison of matrix proteinase mRNA expression in morphologically normal, neoplastic, and metastatic colon tissue and colon biopsies from healthy donors