Effect of afobazole and levodopa on the activity of proline-specific proteinases and adenosine deaminase in blood serum and brain structures of rats with experimental Parkinson's syndrome induced by systemic administration of rotenone | Zendy

Ivanova Ea | Zendy; N. N. Zolotov | Zendy; И. Г. Капица | Zendy; V. F. Pozdnev | Zendy; Е А Вальдман | Zendy; Т. А. Воронина | Zendy

Open Access

Effect of afobazole and levodopa on the activity of proline-specific proteinases and adenosine deaminase in blood serum and brain structures of rats with experimental Parkinson's syndrome induced by systemic administration of rotenone

Author(s) -

Ivanova Ea,

N. N. Zolotov,

И. Г. Капица,

V. F. Pozdnev,

Е А Вальдман,

Т. А. Воронина

Publication year - 2017

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20176306565

Subject(s) - adenosine deaminase , levodopa , parkinson's disease , medicine , pharmacology , systemic administration , adenosine , endocrinology , disease , biology , in vivo , microbiology and biotechnology

Rats with experimental Parkinson’s syndrome induced by seven-day intraperitoneal administration of rotenone at a dose of 2.75 mg/kg have an increased activity of prolylendopeptidase (EC 3.4.21.26, PREP) in blood serum and a decreased activity of adenosine deaminase (EC 3.5.4.4, ADA) in serum and in the prefrontal cortex. PREP and ADA activity in other brain structures (in the striatum, hypothalamus and hippocampus) did not change; dipeptidyl peptidase IV activity (EC 3.4.14.5, DPP-4, CD26) also remained constant in serum and in all the brain structures investigated. Afobazole and levodopa, which exhibit antiparkinsonian activity in this model of Parkinson’s syndrome, decrease elevated PREP activity in serum and increase reduced ADA activity in the prefrontal cortex of rats with the experimental pathology. Meanwhile, treatment with the study drugs was associated with a decrease of ADA activity in the other brain structures.

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