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siRNA/cationic liposome complexes are efficient systems for transmembrane delivery. The aim of this study  was to prepare a novel complex consisted of lipotripeptide OrnOrnGlu(C16H33)2 and siRNA molecule and examined  their physicochemical properties. Electron microscopy study has shown that the siRNA/liposome complex (m/m 1/10)  tends to form sandwich-like structures that may protect nucleic acid from nuclease degradation. Photon correlation  spectroscopy data indicate that the particle size increased after siRNA adding, but did not exceed 300 nm in diameter,  while z-potential of lipoplexes decreased from 22 mV to 14 mV, compared to the empty liposomes thus indicating  positive charge neutralization by negatively charged siRNA. These data allow to hypothesize that such size  and total positive charge could provide efficient cellular uptake by endocytosis. That may have good prospects  for gene silencing therapy.

Physicochemical properties of lipopeptide-based liposomes and their complexes with siRNA