Correction of the oxidant-antioxidant balance in lungs during hyperoxia by liposomal alphalphalpha-tocopherol and retinoids in the experiment

The influence of inhaled liposomes, containing dipalmitoyl phosphatidylcholine and alpha-tocopherol, and liposomes containing dipalmitoyl phosphatidylcholine, retinol and retinoic acid, on parameters of the oxidantantioxidant system in lungs of newborn guinea pigs exposed to hyperoxia during 3 and 14 days has been studied. Administration of both types of liposomes under conditions of prolonged hyperoxia (14 days) results in normalization of glutathione peroxidase activity and prevents elevation of the levels of lipid and protein peroxidation products in bronchoalveolar lavage fluid. Unlike liposomes with alpha-tocopherol, administration of liposomes containing retinoids did not cause the normalizing effect on the content of nonprotein SH-compounds in the bronchoalveolar fluid and contributed to significant reduction of the alpha-tocopherol level in lung tissues.