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The liver has a marked capacity for regeneration. In most cases the liver regeneration is determined  by hepatocytes. The regenerative capacity of hepatocytes is significantly reduced in acute or chronic damage.  In particular, repair mechanisms are not activated in patients with alcoholic cirrhosis. Organ transplantation or advanced  methods of regenerative medicine can help such patients. The promising results were obtained in clinical trials  involving patients with various forms of liver disease who received transplantation of autologous bone marrow  stem cells. However, to improve the effectiveness of such treatment it is necessary to search for more optimal sources  of progenitor cells, as well as to evaluate the possibility of using descendants of these cells differentiated in vitro.  In this study we isolated stromal cells from the liver biopsies of three patients with alcoholic cirrhosis, conducted  their morphological and phenotypic analysis, and evaluated the hepatic potential of these cells in vitro. The stromal cells  isolated from fetal liver were used for comparison. The results of this can serve as a basis for the development  of a new method for the treatment of end-stage liver disease. The stromal cells isolated from the liver biopsies  for a long time proliferate in a culture and this which makes it possible to expand them to large amounts for subsequent  differentiation into hepatocyte-like cells and autologous transplantation.

The hepatic differentiation of adult and fetal liver stromal cells in vitro