Open AccessComposition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)
Author(s) -
S.A. Nikitina,
В. Р. Хабибрахманова,
М. А. Сысоева
Publication year - 2016
Publication title -
biomeditsinskaya khimiya
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.192
H-Index - 15
eISSN - 2310-6972
pISSN - 2310-6905
DOI - 10.18097/pbmc20166204369
Subject(s) - mushroom , inonotus obliquus , triterpene , cancer cell lines , terpene , chemistry , context (archaeology) , biological activity , in vivo , in vitro , agaricales , botany , stereochemistry , biochemistry , biology , food science , cancer cell , cancer , microbiology and biotechnology , medicine , taxonomy (biology) , pathology , paleontology , alternative medicine , genetics
Data on the chemical composition of triterpenic and steroid compounds, isolated from the chaga mushroom grown in natural environment or in a synthetic culture have been summarized. Special attention has been paid to the biological activity of chaga mushroom extracts and these particular compounds against various cancer cell lines in vitro and in vivo. This analysis has demonstrated some common features in inhibition of growth of various cell lines by chaga mushroom components. In this context, the most active are triterpene compounds containing OH group at C-22 and a side chain unsaturated bond.
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