Protective action figurations for superoxide dismutase - chondroitin sulfate - catalase bienzyme conjugate after its medicative administration in endotoxin shock | Zendy

А. В. Максименко | Zendy; A.V. Vavaeva | Zendy; Marina Zvyagintseva | Zendy; A. A. Abramov | Zendy; A. A. Timoshin | Zendy; A.V. Vavaev | Zendy; V. L. Lakomkin | Zendy

Open Access

Protective action figurations for superoxide dismutase - chondroitin sulfate - catalase bienzyme conjugate after its medicative administration in endotoxin shock

Author(s) -

А. В. Максименко,

A.V. Vavaeva,

Marina Zvyagintseva,

A. A. Abramov,

A. A. Timoshin,

A.V. Vavaev,

V. L. Lakomkin

Publication year - 2016

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20166203295

Subject(s) - superoxide dismutase , conjugate , catalase , chemistry , lipopolysaccharide , endotoxic shock , pharmacology , shock (circulatory) , urea , creatinine , dismutase , enzyme , endocrinology , biochemistry , medicine , mathematical analysis , mathematics

Previously it found that the bienzymatic conjugate superoxide dismutase-chondroitin sulfate, catalase (SOD-CHS-CAT) increased the survival rate of rats with endotoxic shock caused by the administration of lipopolysaccharide (LPS). This effect was observed both in preventive (before LPS) and therapeutic conjugate administration (after the administration of LPS). This study shows that the development of endotoxic shock is accompanied by increased levels of NO in the liver, lungs, kidneys, heart; administration of the SOD-CHS-CAT conjugate insignificantly influenced this parameter. At the same time, the changes in blood urea and creatinine suggest the protective effect of the conjugate on renal function, while diverse changes in biochemical parameters studied complicate the formation of the agreed conclusions on the state of other organs.

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