Open AccessCytokines neuroinflammatory reaction to the action of homoaggregatic and liposomal forms of b-amyloid 1-40 in rats
Author(s) -
В. В. Соколік,
Alexander V. Maltsev
Publication year - 2015
Publication title -
biomeditsinskaya khimiya
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.192
H-Index - 15
eISSN - 2310-6972
pISSN - 2310-6905
DOI - 10.18097/pbmc20156103373
Subject(s) - endogeny , hippocampus , pharmacology , chemistry , neuroinflammation , innate immune system , cytokine , systemic administration , proinflammatory cytokine , amyloid (mycology) , inflammation , medicine , neuroscience , immunology , immune system , endocrinology , biology , in vivo , microbiology and biotechnology , inorganic chemistry
An injection model of preclinical stages of Alzheimer's disease has been reproduced in rats. It was accompanied by the decrease in the latent period of conditioned reflex avoidance, increasing levels of endogenous b-amyloid peptide 1-40 and activation of inflammatory cytokines (IL-1b, TNF-a, IL-6, IL-10) in the cerebral cortex, hippocampus and blood serum of experimental animals. We belive that changes identified at the biochemical level are prerequisite to modulate neuronal functions in rats induced by Ab40_Human administration. The toxic effect of exogenous b-amyloid 1-40 homoaggregates caused intense response of the cytokine system, while its liposomal form caused the soft information signal to the activation of innate immunity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom