Mass spectrometry analysis of blood plasma lipidome as method of disease diagnostics, evuation of effectiveness and optimization of drug therapy | Zendy

Petr G. Lokhov | Zendy; Dmitry L. Maslov | Zendy; Elena E. Balashova | Zendy; Oxana P. Trifonova | Zendy; N. V. Medvedeva | Zendy; T. I. Torkhovskaya | Zendy; O. M. Ipatova | Zendy; A. I. Archakov | Zendy; П. П. Малышев | Zendy; В. В. Кухарчук | Zendy; Ekaterina А. Shestakova | Zendy; М. В. Шестакова | Zendy; И. И. Дедов | Zendy

Open Access

Mass spectrometry analysis of blood plasma lipidome as method of disease diagnostics, evuation of effectiveness and optimization of drug therapy

Author(s) -

Petr G. Lokhov,

Dmitry L. Maslov,

Elena E. Balashova,

Oxana P. Trifonova,

N. V. Medvedeva,

T. I. Torkhovskaya,

O. M. Ipatova,

A. I. Archakov,

П. П. Малышев,

В. В. Кухарчук,

Ekaterina А. Shestakova,

М. В. Шестакова,

И. И. Дедов

Publication year - 2015

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20156101007

Subject(s) - lipidome , drug , mass spectrometry , chromatography , pharmacology , lipidomics , medicine , chemistry , biochemistry

A new method for the analysis of blood lipid based on direct mass spectrometry of lipophilic low molecular weight fraction of blood plasma has been considered. Such technique allows quantification of hundreds of various types of lipids and this changes existing concepts on diagnostics of lipid disorders and related diseases. The versatility and quickness of the method significantly simplify its wide use. This method is applicable for diagnostics of atherosclerosis, diabetes, cancer and other diseases. Detalization of plasma lipid composition at the molecular level by means of mass spectrometry allows to assess the effectiveness of therapy and to optimize the drug treatment of cardiovascular diseases by phospholipid preparations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research