Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas | Zendy

О.С. Тимошенко | Zendy; T. A. Gureeva | Zendy; E. V. Kugaevskaya | Zendy; N. I. Solovyeva | Zendy

Open Access

Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas

Author(s) -

О.С. Тимошенко,

T. A. Gureeva,

E. V. Kugaevskaya,

N. I. Solovyeva

Publication year - 2014

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20146006683

Subject(s) - matrix metalloproteinase , furin , metastasis , pathology , metalloproteinase , cancer research , cell , biology , activator (genetics) , endogeny , enzyme , medicine , cancer , gene , endocrinology , biochemistry , genetics

Membrane type 1 matrix metalloproteinase (MT1MMP) is one of matrix metalloproteinases (MMP), which play а key role in tumor invasion and metastasis. The aim of this study was to elucidate the peculiarities of expression of MT1MMP and endogenous regulators of its activity: the activator – furin and the inhibitor – TIMP-2, as invasive factors of squamous cell cervical carcinomas (SCC). The study was carried out using 11 specimens of SCC and 11 specimens of morphologically normal tissue adjacent to the tumor. It was shown that the increase of MT1-MMP and furin expression and low of TIMP-2 expression makes the main contribution to the destructive (invasive) potential of SCC. Moreover, substantial expression of MT1-MMP was registered in the specimens of morphologically normal adjoining to tumor tissue. This expression was found to make an additional contribution to the destructive potential of the cervical tumor.

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