Effect of 17b-estradiol on bioenergetic processes in the heart mitochondria of ovariectomized rats with insulin resistance | Zendy

Nataliia Gorbenko | Zendy; Oleksii Borikov | Zendy; Olha Ivanova | Zendy; Е В Таран | Zendy; T. S. Zvyagina | Zendy

Open Access

Effect of 17b-estradiol on bioenergetic processes in the heart mitochondria of ovariectomized rats with insulin resistance

Author(s) -

Nataliia Gorbenko,

Oleksii Borikov,

Olha Ivanova,

Е В Таран,

T. S. Zvyagina

Publication year - 2014

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20146005576

Subject(s) - ovariectomized rat , medicine , endocrinology , insulin resistance , bioenergetics , oxidative phosphorylation , mitochondrion , respiration , estrogen , insulin , fructose , chemistry , phosphorylation , biology , biochemistry , anatomy

Тhe bioenergetic processes in the heart mitochondria of Wistar rats with fructose-induced insulin resistance was investigated in female animals with different estrogen status. Respiration studies on isolated heart mitochondria by the polarographic method revealed that estrogen deficiency reduced complex IV activity, while its combination with high-fructose diet induced additional disturbances in the coupling of respiration and oxidative phosphorylation at the level of complex I of the electron transport chain. Exogenous 17b-estradiol inhibited the development of mitochondrial dysfunction in cardiomyocytes of ovariectomized rats with insulin resistance.

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