Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol | Zendy

N.A. Pravosudova | Zendy; I.O. Bykova | Zendy

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Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol

Author(s) -

N.A. Pravosudova,

I.O. Bykova

Publication year - 2014

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20146005548

Subject(s) - haloperidol , carboxypeptidase , medicine , endocrinology , pharmacology , psychology , chemistry , dopamine , biochemistry , enzyme

The influence of a single injection of haloperidol on basic carboxypeptidases (biologically active peptide processing enzymes) activity in rat tissues was studied. Acute exposure to haloperidol increased the activity of carboxypeptidases H (CP H) in hypothalamic-pituitary-adrenal system and cerebellum and reduced such activity in testes. Multidirectional changes of PMSF-inhibited carboxypeptidases activity (PMSF-CP) were observed after a single haloperidol injection in all studied tissues except testes. It is suggested that changes of CP H and PMSF-CP activity might affect levels of regulatory peptides in the brain and blood and thus may be involved in general and side effects of haloperidol on the organism.

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