Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells | Zendy

Victor Tkachev | Zendy; M. V. Zaikovskaya | Zendy; A. V. Troitsky | Zendy; Н. Г. Лузгина | Zendy; V. А. Shkurupy | Zendy

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Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells

Author(s) -

Victor Tkachev,

M. V. Zaikovskaya,

A. V. Troitsky,

Н. Г. Лузгина,

V. А. Shkurupy

Publication year - 2013

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20135901081

Subject(s) - reactive oxygen species , oxidative stress , antioxidant , chemistry , intracellular , in vitro , in vivo , phagocytosis , oxygen , cytotoxic t cell , biochemistry , oxidative phosphorylation , microbiology and biotechnology , biology , organic chemistry

The effects of oxidized dextrans of different molecular weight on reactive oxygen species production and transmembrane mitochondrial potential of macrophages and neutrophils have been studied in vivo and in vitro . Oxidised dextrans demonstrated moderate direct antioxidant ability but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.

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