Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth | Zendy

V. N. Zinov’eva | Zendy; А. А. Спасов | Zendy

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Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth

Author(s) -

V. N. Zinov’eva,

А. А. Спасов

Publication year - 2012

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20125803257

Subject(s) - polyphenol , angiogenesis , cell cycle , carcinogenesis , cancer research , signal transduction , apoptosis , tumor promotion , kinase , cyclin , microbiology and biotechnology , metastasis , chemistry , cell cycle checkpoint , cancer , biology , biochemistry , gene , genetics , antioxidant

Mechanisms of suppression of carcinogenesis promotion/progression by plant polyphenols have been considered. They can decrease cyclins and cycline dependent kinases and activate inhibitor proteins in tumor cells that results in cell cycle arrest. Plant polyphenols can induce apoptosis by modulating anti/proapoptotic proteins and also can inhibit tumor metastasis and angiogenesis. Polyphenols act through the regulation of cell signal transduction and gene expression.

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