A new approach to studying the autoxidation of adrenaline: possibility of the determination of superoxide dismutase activity and the antioxidant properties of various preparations by polarography | Zendy

Т. В. Сирота | Zendy

Open Access

A new approach to studying the autoxidation of adrenaline: possibility of the determination of superoxide dismutase activity and the antioxidant properties of various preparations by polarography

Author(s) -

Т. В. Сирота

Publication year - 2012

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20125801077

Subject(s) - adrenochrome , autoxidation , chemistry , superoxide dismutase , superoxide , antioxidant , oxygen , polarography , radical , reactive oxygen species , organic chemistry , biochemistry , epinephrine , inorganic chemistry , enzyme , endocrinology , medicine

The reaction of adrenaline autoxidation in an alkaline buffer with the formation of superoxide radicals and the product of its oxidation, adrenochrome, which models the quinoid pathway of adrenaline conversion in the body, is accompanied by oxygen consumption. This reaction is applicable for polarographic determination of the activity of superoxide dismutase and the antioxidant properties of biological and chemical compounds, it is based on evaluation of the latent period and the rate of oxygen consumption, which are measured in the presence of the compounds examined. It was assumed that the neuro- and cardiotoxicity of quinone products of adrenaline oxidation is related not only to their "own" properties and reactive oxygen species formed but also the hypoxia of those regions of the cell and tissue where the quinoid oxidation of adrenaline occurs.

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