The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo | Zendy

G. V. Rаmenskаya | Zendy; I. E. Shohin | Zendy; A. Yu. Sаvchenko | Zendy; E. A. Volkova | Zendy

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The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo

Author(s) -

G. V. Rаmenskаya,

I. E. Shohin,

A. Yu. Sаvchenko,

E. A. Volkova

Publication year - 2011

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20115705482

Subject(s) - in vivo , dissolution testing , dissolution , computer science , drug , drug delivery , chemistry , pharmacology , medicine , biology , biopharmaceutics classification system , microbiology and biotechnology , organic chemistry

The review deals with the modern tool for modeling of drug behavior in vivo, - the dissolution test in biorelevant media, imitating gastrointestinal fluids. The formulations and preparation methods of fasted state simulation intestinal fluid, FaSSIF and fed state simulation intestinal fluid, FeSSIF, are defined. In addition, the dissolution characteristics of APIs from different BCS classes in biorelevant media are described. Possible applications of biorelevant media in regulatory practice and science are also shown.

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