Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients | Zendy

K. V. Lisitskaya | Zendy; Л. С. Еремина | Zendy; А. В. Иванов | Zendy; M. A. Kovalyova | Zendy; В. Е. Охриц | Zendy; I. Yu. Toropygin | Zendy; L. I. Kovalyov | Zendy; Shishkin Ss | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients

Author(s) -

K. V. Lisitskaya,

Л. С. Еремина,

А. В. Иванов,

M. A. Kovalyova,

В. Е. Охриц,

I. Yu. Toropygin,

L. I. Kovalyov,

Shishkin Ss

Publication year - 2011

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20115704392

Subject(s) - lncap , prostate cancer , hyperplasia , biomarker , gene isoform , prostate , medicine , cancer , pathology , biology , microbiology and biotechnology , cancer research , gene , biochemistry

Two isoforms of Dj-1 protein were identified using a proteomic study in tissue specimens from two groups of patients with confirmed benign prostate hyperplasia (BPH) and prostate cancer (PCa). Dj-1 was also found in the cell lines РС-3, DU-145, LNCaP, BPH-1, and the lowest level of Dj-1 was found in BPH-1. Immunochemical study (ELISA) of serum levels of Dj-1, Bcl-2, IGF-1 and IGFBP-3 proteins revealed statistically significant distinctions between two groups of patients (р=0,004, Mann-Whitney test) only for Dj-1. Taken together, these data suggest that Dj-1 protein is a perspective biomarker candidate for PCa.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research