Open AccessInfluence of α-lipoic acid on liver glutathione system of healthy and ehrlich ascites carcinoma transplanted mice
Author(s) -
Л. С. Колесниченко,
В. С. Лалетин,
V. I. Kulinsky
Publication year - 2011
Publication title -
biomeditsinskaya khimiya
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.192
H-Index - 15
eISSN - 2310-6972
pISSN - 2310-6905
DOI - 10.18097/pbmc20115702219
Subject(s) - glutathione , ehrlich ascites carcinoma , lipoic acid , ascites , ehrlich ascites , chemistry , cancer research , biology , biochemistry , medicine , antioxidant , tumor cells , enzyme
Influence of α-lipoic acid (LA) on liver glutathione system of Ehrlich ascites carcinoma (EAC) transplanted mice was studied. LA causes multidirectional influence on glutathione system of healthy mice. EAC transforms LA influence, strengthening prooxidative effects more expressed at introduction in early terms after inoculation of the tumor. The mechanism explaining realization of LA prooxidative effects as a result of interaction with glutathione system is suggested.
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