Synthetic peptide vaccines
Author(s) -
Alexander Moysa,
Е. Ф. Колесанова
Publication year - 2011
Publication title -
biomeditsinskaya khimiya
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.192
H-Index - 15
eISSN - 2310-6972
pISSN - 2310-6905
DOI - 10.18097/pbmc20115701014
Subject(s) - malaria , infectious disease (medical specialty) , malaria vaccine , peptide , virology , biopharmaceutical , computational biology , proteomics , biology , immunology , medicine , plasmodium falciparum , disease , microbiology and biotechnology , gene , genetics , biochemistry , pathology
This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections. An important role for the development and selection of efficient adjuvants for peptide immunogens is noted. Examples of synthetic peptide vaccine developments against three infectious diseases (malaria, hepatitis C, and foot-and-mouth disease) are given.
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