Detection of telomerase activity in gastric cancer | Zendy

L. V. Svinareva | Zendy; А.И. Глухов | Zendy; О.В. Зимник | Zendy; И И Быков | Zendy; Т В Хоробрых | Zendy; V. I. SHVETS | Zendy

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Detection of telomerase activity in gastric cancer

Author(s) -

L. V. Svinareva,

А.И. Глухов,

О.В. Зимник,

И И Быков,

Т В Хоробрых,

V. I. SHVETS

Publication year - 2010

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20105605602

Subject(s) - telomerase , cancer , gastric lymphoma , cancer research , lymphoma , malignant transformation , medicine , pathology , chemistry , gene , biochemistry

Telomerase activity (TA) was examined in gastric adenocarcinomas and gastric lymphoma using a modified TRAP assay. TA was present in 16 of 18 (89%) gastric adenocarcinomas and in gastric lymphoma, whereas no TA was detected in normal tissue. Almost all samples had "high" and "very high" TA levels. Telomerase is undoubtedly associated with the process of malignant transformation and therefore can be an important marker for diagnostics of gastric cancer.

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