Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids | Zendy

В. Р. Хайруллина | Zendy; Г. П. Тарасов | Zendy; A.Ja. Gerchikov | Zendy; F. S. Zarydiy | Zendy; L. A. Tjurina | Zendy

Open Access

Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids

Author(s) -

В. Р. Хайруллина,

Г. П. Тарасов,

A.Ja. Gerchikov,

F. S. Zarydiy,

L. A. Tjurina

Publication year - 2010

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20105604471

Subject(s) - acetamide , chemistry , combinatorial chemistry , pharmacology , structure–activity relationship , medicine , organic chemistry , biochemistry , in vitro

Using the computer system SARD-21 (Structure Activity Relationship & Design) structural features of high- and low-effective anti-arrhythmic agents have been recognized and the influence of these features on the anti-arrhythmic properties has been evaluated. This information has been used for generation of the model for prediction of anti-arrhythmic effectiveness of pharmaceutical preparations with the 82%-level of recognition by two methods. The recognized structural parameters may be successfully used for design of new highly effective anti-arrhythmic drugs, and also for modification of structures of known anti-arrhythmic drugs for the increase of effectiveness of their anti-arrhythmic action.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research