Molecular mechanisms of genetic damages of the myocardium in cardiomyopathy | Zendy

A.G. Hasanov | Zendy; T.V. Bershova | Zendy; Е. Н. Басаргина | Zendy; Bakanov Mi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Molecular mechanisms of genetic damages of the myocardium in cardiomyopathy

Author(s) -

A.G. Hasanov,

T.V. Bershova,

Е. Н. Басаргина,

Bakanov Mi

Publication year - 2010

Publication title -

biomeditsinskaya khimiya

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.192

H-Index - 15

eISSN - 2310-6972

pISSN - 2310-6905

DOI - 10.18097/pbmc20105603319

Subject(s) - hypertrophic cardiomyopathy , extracellular matrix , cardiomyopathy , dilated cardiomyopathy , cytoskeleton , extracellular , medicine , chemistry , microbiology and biotechnology , cardiology , heart failure , cell , biology , biochemistry

The review highlighted problems of reorganization of myocardical contractile and cytoskeletal proteins in cardiomyopathy (CM). The role of the genetic factors coding contractile proteins, proteins of thin and thick filaments, and also extracellular matrix proteins in processes of formation and development of hypertrophic (HCM) and dilated (DCM) cardiomyopathy are analyzed. The mechanisms responsible for the changes in cardiac proteins on regulation involved into force generation, its transfer, recycling ATP, impairments in transmembranal signals, that finally lead to cardiac cell dysfunction determining various manifestations of CM are considered.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research