Development and characterization of a photocurable alginate bioink for three-dimensional bioprinting | Zendy

Hussein Mishbak | Zendy; Glen Cooper | Zendy; Paulo Bártolo | Zendy

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Development and characterization of a photocurable alginate bioink for three-dimensional bioprinting

Author(s) -

Hussein Mishbak,

Glen Cooper,

Paulo Bártolo

Publication year - 2019

Publication title -

international journal of bioprinting

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.014

H-Index - 24

eISSN - 2424-7723

pISSN - 2424-8002

DOI - 10.18063/ijb.v5i2.189

Subject(s) - photoinitiator , photopolymer , materials science , methacrylate , biocompatible material , polymerization , swelling , chemical engineering , dissolution , rheology , polymer , polymer chemistry , composite material , biomedical engineering , monomer , medicine , engineering

Alginate is a biocompatible material suitable for biomedical applications, which can be processed under mild conditions on irradiation. This paper investigates the preparation and the rheological behavior of different pre-polymerized and polymerized alginate methacrylate systems for three-dimensional photopolymerization bioprinting. The effect of the functionalization time on the mechanical, morphological, swelling, and degradation characteristics of cross-linked alginate hydrogel is also discussed. Alginate was chemically-modified with methacrylate groups and different reaction times considered. Photocurable alginate systems were prepared by dissolving functionalized alginate with 0.5- 1.5% w/v photoinitiator solutions and cross-linked by ultraviolet light (8 mW/cm for 8 minutes).

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