Printing amphotericin B on microneedles using matrixassisted pulsed laser evaporation | Zendy

Roger Sachan | Zendy; Panupong Jaipan | Zendy; Jennifer Zhang | Zendy; Simone Degan | Zendy; Detlev Erdmann | Zendy; Jonathan Tedesco | Zendy; Lyndsi Vanderwal | Zendy; Shane J. Stafslien | Zendy; Irieguț | Zendy; Anita Ioana Vișan | Zendy; G. Dorcioman | Zendy; G. Socol | Zendy; R. Cristescu | Zendy; Douglas B. Chrisey | Zendy; Roger J. Narayan | Zendy

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Printing amphotericin B on microneedles using matrixassisted pulsed laser evaporation

Author(s) -

Roger Sachan,

Panupong Jaipan,

Jennifer Zhang,

Simone Degan,

Detlev Erdmann,

Jonathan Tedesco,

Lyndsi Vanderwal,

Shane J. Stafslien,

Irieguț,

Anita Ioana Vișan,

G. Dorcioman,

G. Socol,

R. Cristescu,

Douglas B. Chrisey,

Roger J. Narayan

Publication year - 2017

Publication title -

international journal of bioprinting

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.014

H-Index - 24

eISSN - 2424-7723

pISSN - 2424-8002

DOI - 10.18063/ijb.2017.02.004

Subject(s) - amphotericin b , transdermal , materials science , evaporation , agar , solubility , candida albicans , yeast , microbiology and biotechnology , biomedical engineering , chemistry , antifungal , pharmacology , biology , medicine , biochemistry , organic chemistry , physics , genetics , bacteria , thermodynamics

Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentration-dependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles.

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