Anti-tumor Role of MicroRNA-4782-3p in Epithelial Ovarian Cancer

Ovarian cancer ranks fifth in cancer death among women. The 5-year relative survival of all stages ovarian cancer is 47%. Identification of new molecular targets is required for the development of targeted therapy. MicroRNA (miRNA) are small, highly conserved RNA molecules involved in the regulation of gene expression. miR-4782-3p has shown tumor-suppressive activities in non-small cell lung cancer. Thus, it is possible that miR-4782-3p may play a role in the development of ovarian cancer. Herein, we analyzed the levels of miR-4782-3p in ovarian cancer tissue and cell lines and tested the function of miR-4782-3p in cell proliferation and cell apoptosis. We found that miR4782-3p plays an inhibitory role in ovarian cancer growth. The data showed that ovarian cancer tissue and cell lines showed lower levels of miR-4782-3p, which inhibited cell growth and increased cell apoptosis. Moreover, PDGFRα was identified as a direct target of miR-4782-3p. In conclusion, our data indicated that miR-4782-3p has an inhibitory impact on ovarian cancer.