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Systemic lupus erythematosus (SLE) is an autoimmune disease in which multiplefactors induce an uncontrolled immune response in an individual who isgenetically predisposed, presenting a variety of clinical manifestations that oftenbecome a real diagnostic challenge and Therapeutic as in the case of their skinpresentations. We will now describe a case of a male patient with a SLEdiagnosis with severe extensive skin lesions with clinical and histopathologicaldiagnosis suggestive of blistering lupus refractory to standard treatment withcorticosteroid therapy and immunomodulators with a morphologic evolution intheir course, which then requires the initiation of biological therapy withBelimumab observed a significant clinical remission of the lesions and alsocontributing to decrease the doses of corticosteroids used since their entry. Wewill review aspects related to SLE in men in terms of epidemiology, cutaneousmanifestations, histopathological findings, differential diagnosis and currenttherapeutic options.

Lupus ampolloso: un verdadero reto diagnóstico y terapéutico