BAZI İMİDAZOL VE TİYAZOL BAĞLI ASETAMİT BİLEŞİKLERİNİN ASİTLİK SABİTLERİNİN İNCELENMESİ VE DEĞERLENDİRİLMESİ

In this work, the effect of substituents on the acidity constants of some acetamide derivatives was investigated. The acidity constants of nine acetamide derivatives were determined at 25 °C using a UV spectrophotometric method. When the molecules possessed different substituents the values of the acidity constants changed from 6.01 to 8.22 for the first protonation and from 3.07 to 4.73 for the second protonation. The first protonation under these circumstances was observed to occur on the nitrogen atom of the 2-mercaptoimidazole ring. The second protonation was observed to occur on the nitrogen atom of the thiazole ring.