English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Postmortem reditribution (PMR) refers to the changes that occur in drug concentrations after death. It involves the redistribution of drugs into blood from solid organs such as the lungs, liver and myocardium. Postmortem drug concentrations show variations depending on sampling sites and characteristics of the drugs. Drug properties such as volume of distribution, lipophilicity, and pKa are important factors. Basic, lipophilic drugs with a volume of distribution greater than 3 l/kg are most likely to undergo PMR.The anatomical location of blood sampling can influence the drug concentration. Blood collected at autopsy is an important biological sample and consist of cardiac and peripheral blood. The cardiac blood concentrations are, in general, higher than peripheral blood concentrations. Postmortem drug concentrations in peripheral blood were reported to be similar to antemortem drug concentrations. Therefore blood collected from peripheral sites is recommended for drug analysis and interpretation. While many laboratories is determinig the redistribution in postmortem cases, they use cardiac:peripheric blood (C/P) concentration ratio. When this ratio is substantially greater than unity, the drug is considered to exhibit postmortem redistribution. The liver to peripheral blood (L/P) ratio is also evaluated as a marker of postmortem redistribution because of postmortem drug concentration is  more stable in tissues. Confidence of drug concentration measured in postmortem blood is decreased and the importance of tissue analysis come back on the agenda again.The interpretation of concentrations of drugs measured in the postmortem period is complex. In this reason, in our study “What is the postmortem redistribution and Which biological samples should be taken for the correct and reliable assessment of the toxicological data? ” answers to the questions will be presented in the literature.Keywords: Drug, Postmortem Redistribution, Forensic Toxicology

İlaçların Postmortem Yeniden Dağılımı Toksikolojik Örnek Alma Veri Değerlendirme ve Yorumlama